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Kumar Nallasivan, P.
- RP-HPLC Method for Simultaneous Estimation of Tramadol HCl and Paracetamol Bulk Drug and its Combined Dosage Form
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Authors
Affiliations
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 552-554Abstract
This work is concerned with application of simple, accurate, precise and highly selective reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Tramadol HCl and Paracetamol in combined dosage form. Chromatographic separation was achieved isocratically at room temperature on phenomenex C18 column (250×4.6 mm) with a mobile phase composed of 5% Tri-fluoroaceticacid in water:Acetonitrile:Methanol in the ratio of 70:20:10% v/v/v at flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 254 nm. The retention time of Tramadol HCl and Paracetamol was found to be 3.890±0.5 min and 1.990±0.5 min respectively. The method was found to be linear in the range of 0.1-10 μg/ml with mean recovery of 98.96% for Tramadol HCl and 99.11% for Paracetamol. The correlation coefficients for all components are close to 1. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of Tramadol HCl and Paracetamol in routine analysis.Keywords
Tramadol HCl, Paracetamol, RP-HPLC.- Computer Aided Docking Studies on Antiviral Drugs for Bird Flu
Abstract Views :178 |
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Authors
R. Siva Kumar
1,
Shaik Nafeez Basha
1,
P. Kumar Nallasivan
1,
W. D. Sam Solomon
1,
R. Venkatnarayanan
1
Affiliations
1 Dept. of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, (T.N.), IN
1 Dept. of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, (T.N.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 370-373Abstract
The Protein-Ligand interaction plays a significant role in structural based drug designing. The highly pathogenic influenza A virus subtype H5N1 virus is an emerging avian influenza virus that has been causing global concern as a potential pandemic threat. It is often referred to simply as "bird flu" or "avian influenza". In our research work we have taken influenza A virus H5N1 receptor. The receptor was docked to the commercially available drugs zanamivir and oseltamivir and the energy value obtained are as follows; zanamivir (-231.74) and oseltamivir (-243.74) using the HEX docking software. We tried to improve the binding efficiency and steric compatibility of zanamivir against N5N1 receptor. Several modifications were made to the probable functional groups which were interacting with the receptor molecule. Analogs of this drug molecule were prepared using ACD ChemSketch and docked using HeX docking software. Zanamivir analog 3 and oseltamivir analog 5 were detected with significant energy values and probable lead molecules. The Modified drugs was sketched using Chemsketch were found to be better than the conventional drugs available. Further from this work we can improve the steric compatibility and then ADME properties of the Analogs can be analyzed using Inslico ADME tools available.Keywords
Bird Flu, Chemsketch, Docking, Hex, Rasmol.- Simultaneous RP-HPLC Estimation of Nitazoxanide and Ofloxacin in Tablet Dosage Forms
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Authors
Affiliations
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN